Daidzein and genistein but not their glucosides are absorbed from the rat stomach

FEBS Letters

Iwai, Yukihiko²  Yamakoshi, Jun²  Piskula, Mariusz K¹ 

[1] Noda Institute for Scientific Research, 399 Noda City, Chiba 278-0037, Japan;R and D Division of Kikkoman Corporation, 399 Noda City, Chiba 278-0037, Japan

关键词: Daidzein;    Genistein;    Isoflavonoid absorption;    Plasma;    Stomach;    Rat;   

DOI  :  10.1016/S0014-5793(99)00307-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Absorption of isoflavone aglycones and glucosides was compared in rats. Daidzein, genistein, daidzin and genistin were orally administered at a dose of 7.9 μmol/kg in 25 mM Na₂CO₃ and next their metabolite concentration in blood plasma was monitored for 30 min. After isoflavone glucosides administration, their metabolites appeared in plasma with a few minutes delay as compared to aglycones, which suggested that aglycones, but not glucosides, were absorbed already in the rat stomach. This observation was confirmed when absorption site was restricted solely to the stomach and absorption was shown to be independent of the vehicle pH used for administration.

【 授权许可】

Unknown