Cyclosporin A inhibits H2O2‐induced apoptosis of human fibroblasts

FEBS Letters

Ito, Koichi¹  Sugano, Naoyuki¹  Murai, Seidai¹ 

[1] Nihon University School of Dentistry, Department of Periodontology, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-8310, Japan

关键词: Apoptosis;    Cyclosporin A;    Fibroblast;    Hydrogen peroxide;   

DOI  :  10.1016/S0014-5793(99)00312-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Several clinical studies have shown that cyclosporin A (CsA) is effective for treating a variety of chronic inflammatory and autoimmune diseases. Because reactive oxygen species are believed to play a key role in the development of these diseases, causing cell apoptosis, we investigated whether CsA inhibits H₂O₂-induced apoptosis. Preincubation of human fibroblasts with CsA dose-dependently decreased H₂O₂-induced apoptosis. Apoptosis suppression by CsA was correlated with the prevention of mitochondrial dysfunction and caspase activation. Thus, our results suggest that the inhibition of apoptosis by CsA may at least partly contribute to the anti-inflammatory effect of CsA.

【 授权许可】

Unknown