Cell membrane dynamics and the induction of apoptosis by lipid compounds

FEBS Letters

Oshima, Mieko¹  Iwasaki, Chizu²  Yasugi, Etsuko¹  Fujimoto, Keiji²  Kawaguchi, Haruma² 

[1] Research Institute, International Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162, Japan;Department of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan

关键词: Apoptosis;    Membrane fluidity;    Lipid compound;    Isoprenoid;    Apoptosis inducer;    Emulsion;   

DOI  :  10.1016/S0014-5793(99)00204-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

To investigate the induction of apoptosis by some lipid compounds which are a potent inducer of apoptosis, the plasma membrane fluidity of U937 cells was measured using the fluorescent probe, pyrene. The increase of the membrane fluidity was observed immediately after the treatment of cells with lipid inducers. We also found that the trigger of apoptosis was pulled within 30 min after treatment. Data from the dynamic light scattering experiment indicated that lipid inducers were dissolved to form the emulsion. At the very early stage of apoptosis, possibly, the well-controlled transfer of lipid inducers from the emulsion to the lipid layer of cells can bring about the increase of membrane dynamics which might lead to the induction of apoptosis.

【 授权许可】

Unknown