Cardiomegaly in the juvenile visceral steatosis (JVS) mouse is reduced with acute elevation of heart short‐chain acyl‐carnitine level after l‐carnitine injection

FEBS Letters

Kamido, Hiroshi⁵  Saheki, Takeyori⁴  Shima, Kenji³  Kudo, Tomoko³  Lu, Kang-mo³  Harashima, Hideyoshi¹  Ozaki, Kiyokazu²  Hayashi, Miyuki³  Ono, Akira⁵  Horiuchi, Masahisa⁴  Kuwajima, Masamichi³  Sei, Masako³ 

[1] Faculty of Pharmaceutical Sciences, The University of Tokushima, Tokushima, Japan;Research Institute of Drug Safety, Setsunan University, Setsunan, Japan;Department of Laboratory Medicine, School of Medicine, The University of Tokushima, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan;Department of Biochemistry, Faculty of Medicine, Kagoshima University, Kagoshima, Japan;Second Department of Internal Medicine, Osaka University Medical School, Osaka, Japan

关键词: Cardiomegaly;    Carnitine acetyltransferase;    Carnitine transporter;    Juvenile visceral steatosis mouse;    ANOVA;    analysis of variance;    JVS;    juvenile visceral steatosis;    CAT;    carnitine acetyltransferase;   

DOI  :  10.1016/S0014-5793(98)01732-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The long-term administration of l-carnitine was very effective in preventing cardiomegaly in juvenile visceral steatosis (JVS) mice, which was confirmed by heart weight as well as the lipid contents in heart tissue. After i.p. injection of l-carnitine, the concentration of free carnitine in heart remained constant, although serum free carnitine level increased up to 80-fold. On the other hand, a significant increase in short-chain acyl-carnitine level in heart was observed. These results suggest that increased levels of short-chain acyl-carnitine, not free carnitine, might be a key compound in the protective effect of l-carnitine administration in JVS mice.

【 授权许可】

Unknown