9‐cis Retinoic acid induces the expression of the uncoupling protein‐2 gene in brown adipocytes

FEBS Letters

Iglesias, R¹  Viñas, O¹  Valmaseda, A¹  Giralt, M¹  Carmona, M.C¹  Villarroya, F¹  Mampel, T¹ 

[1] Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Avda Diagonal 645, 08028 Barcelona, Spain

关键词: Brown adipose tissue;    Uncoupling protein-2;    Uncoupling protein-1;    9-cis Retinoic acid;    Thermogenesis;    BAT;    brown adipose tissue;    UCP1;    uncoupling protein-1;    UCP2;    uncoupling protein-2;    IGF-1;    insulin-like growth factor 1;    PPAR;    peroxisome proliferator-activated receptor;    9-cis RA;    9-cis retinoic acid;    T3;    triiodothyronine;    all-trans RA;    all-trans retinoic acid;    COII;    cytochrome c oxidase subunit II;    15d-PGJ2;    15-deoxy-Δ-12;    14-prostaglandin J2;    RAR;    retinoic acid receptor;    RXR;    retinoid X receptor;   

DOI  :  10.1016/S0014-5793(98)01598-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The expression of uncoupling protein-2 (UCP2) mRNA is up-regulated during the differentiation of brown adipocytes in primary culture. When differentiation of brown adipocytes is impaired, UCP2 mRNA expression is down-regulated. 9-cis Retinoic acid causes a dose-dependent induction of UCP2 mRNA levels in brown adipocytes, whereas all-trans retinoic acid has no effect. Specific agonists of retinoid X receptors (RXR) induce UCP2 mRNA expression, whereas specific activators of retinoic acid receptors do not. 9-cis Retinoic acid, acting through RXR receptors, is identified as a major regulator of the expression of the UCP2 gene in the brown fat cell.

【 授权许可】

Unknown