Identification of a long variant of mRNA encoding the NR3 subunit of the NMDA receptor: its regional distribution and developmental expression in the rat brain

FEBS Letters

Lidow, Michael S.²  Shipley, Michael T.¹  Margolis, Frank L.¹  Sun, Lixin² 

[1] Department of Anatomy and Neurobiology, University of Maryland, Baltimore, MD 21201, USA;Department of Oral and Craniofacial Biological Sciences, University of Maryland, 5-A-12, HHH, 666 W. Baltimore St., Baltimore, MD 21201, USA

关键词: NMDA receptor;    NR3 subunit;    Variant;    Cloning;    Phosphorylation;    Distribution;    Development;   

DOI  :  10.1016/S0014-5793(98)01590-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A longer variant of rat mRNA encoding the NR3 subunit of the NMDA receptor has been identified. It contains a 60-bp insertion at the nucleotide position 3007 in the intracellular domain of the C-terminal of the previously cloned variant. Therefore, the NR3 mRNA exists in at least two variants – with the insert (NR3-long; NR3-l) and without the insert (NR3-short; NR3-s). The NR3-l variant is expressed throughout the adult rat brain. Moreover, this variant predominates in the occipital and entorhinal cortices, thalamus and cerebellum. Analysis of NR3-l development indicates that it is regulated in a region-specific manner.

【 授权许可】

Unknown