Wavelength specific activation of PI 3‐kinase by UVB irradiation

FEBS Letters

Kabuyama, Yukihito¹  Homma, Yoshimi¹  Hamaya, Mikiko¹ 

[1] Department of Biomolecular Science, Institute of Biomedical Sciences, Fukushima Medical College, Hikariga-oka, Fukushima 960-1295, Japan

关键词: Ultraviolet B;    Phosphatidylinositol 3-kinase;    Cell death;    Tyrosine kinase;    Reactive oxygen intermediate;    UVB;    ultraviolet B;    PI 3-kinase;    phosphatidylinositol 3-kinase;    ROI;    reactive oxygen intermediate;    PIP3;    phosphatidylinositol 3;    4;    5-trisphosphate;    PKB;    protein kinase B;   

DOI  :  10.1016/S0014-5793(98)01565-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We investigated the effect of UVB irradiation on phospholipid metabolism using normal human diploid skin fibroblasts. When cells were exposed to monochromatic UV light, the intracellular PIP₃ level was increased within 1 min in a wavelength-specific manner. The increase was most marked in the UVB range and was inhibited by a PI 3-kinase inhibitor, tyrosine kinase inhibitor, or antioxidant reagents. Furthermore, the decrease of cell viability induced by UVB irradiation was significantly blocked by wortmannin. These results suggest that PI 3-kinase activation is involved in novel cellular responses specific for UVB that lead to cell death.

【 授权许可】

Unknown