Ultraviolet B irradiation increases endothelin‐1 and endothelin receptor expression in cultured human keratinocytes

FEBS Letters

Sato, Chiyo²  Tsuboi, Ryoji²  Sakurai, Takeshi¹  Ogawa, Hideoki²  Oshita, Yoshitami²  Goto, Katsutoshi¹  Hama, Hiroshi¹ 

[1] Department of Pharmacology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305, Japan;Department of Dermatology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113, Japan

关键词: Endothelin-1;    Endothelin receptor;    Ultraviolet B;    Keratinocyte;    ET;    endothelin;    UVB;    ultraviolet B;   

DOI  :  10.1016/0014-5793(95)00912-S

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The effect of ultraviolet B (UVB) irradiation on endothelin-1 (ET-1) and ET receptor expression was examined using cultured normal human keratinocytes. Keratinocytes secreted ET-1 in the medium at a level of 2.1 pg/day/10⁵ cells. UVB irradiation up to 10 mJ/cm² increased ET-1 secretion 3-fold, and potentiated expression of mRNA for ET-1. Both ET_A and ET_B receptor mRNAs were detected in keratinocytes, and their expression was up-regulated by 5 mJ/cm² UVB irradiation.

【 授权许可】

Unknown