Neuronal expression of fractalkine in the presence and absence of inflammation

FEBS Letters

Iglesias, Antonio³  Schubart, Anna³  Schwaeble, Wilhelm J²  Schäfer, Martin K.-H⁴  Weihe, Eberhard⁴  Schall, Thomas J¹  Linington, Christopher³  Trinder, Peter K.E²  Stover, Cordula M²  Lynch, Nicholas J⁴  Dairaghi, Daniel J¹ 

[1] ChemoCentryx, 1539 Industrial Road, San Carlos, CA 94306, USA;Department of Microbiology and Immunology, University of Leicester, P.O. Box 138, Leicester LE1 9HN, UK;Max-Planck Institute for Psychiatry, 82152 Martinsried, Germany;Department of Anatomy and Cell Biology, University of Marburg, 35033 Marburg, Germany

关键词: Fractalkine;    Experimentally induced allergic encephalomyelitis;    Inflammation;    Neuronal expression;   

DOI  :  10.1016/S0014-5793(98)01384-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Fractalkine is the only as yet known member of a novel class of chemokines. Besides its novel Cys-X-X-X-Cys motif, fractalkine exhibits features which have not been described for any other member of the chemokine family, including its unusual size (397 amino acids human, 395 mouse) and the possession of a transmembrane anchor, from which a soluble form may be released by extracellular cleavage. This report demonstrates the abundant mRNA and fractalkine protein expression in neuronal cells. The neuronal expression of fractalkine mRNA is unaffected by experimentally induced inflammation of central nervous tissue.

【 授权许可】

Unknown