Molecular anatomy of the human glucose 6‐phosphate dehydrogenase core promoter

FEBS Letters

Ursini, Matilde Valeria¹  Franzè, Annamaria¹  Sanzari, Emma¹  Fusco, Francesca¹  Martini, Giuseppe¹  Santoro, Antonietta¹  Ferrante, Maria Immacolata¹ 

[1] Istituto Internazionale di Genetica e Biofisica, CNR, Via Marconi 12, 80125 Naples, Italy

关键词: Housekeeping gene;    Initiator;    Glucose 6-phosphate dehydrogenase;    Sp1;   

DOI  :  10.1016/S0014-5793(98)01259-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The gene encoding glucose 6-phosphate dehydrogenase (G6PD), which plays a pivotal role in cell defense against oxidative stress, is ubiquitously expressed at widely different levels in various tissues; moreover, G6PD expression is regulated by a number of stimuli. In this study we have analyzed the molecular anatomy of the G6PD core promoter. Our results indicate that the G6PD promoter is more complex than previously assumed; G6PD expression is under the control of several elements that are all required for correct promoter functioning and, furthermore, a still unidentified mammalian specific factor is needed.

【 授权许可】

Unknown