Diacylglycerol pyrophosphate: a novel metabolite in the Trypanosoma cruzi phosphatidic acid metabolism

FEBS Letters

Machado-Domenech, Estela¹  Santander, Verónica¹  Marchesini, Norma¹ 

[1] Quı́mica Biológica, Facultad de Ciencias Exactas, Fı́sico-Quı́micas y Naturales, Universidad Nacional de Rı́o Cuarto, 5800 Rı́o Cuarto, Córdoba, Argentina

关键词: Diacylglycerol pyrophosphate;    Diacylglycerol kinase;    Phosphatidate kinase;    Phosphatidic acid;    Phospholipid;    Trypanosoma cruzi;    DG;    diacylglycerol;    DG-k;    diacylglycerol kinase;    DGPP;    diacylglycerol pyrophosphate;    LPA;    lyso-phosphatidic acid;    PA;    phosphatidic acid;    PAP;    PA phosphatase;    PI;    phosphatidylinositol phosphate;    PIP;    phosphatidylinositol 4-phosphate;    PIP2;    phosphatidylinositol 4;    5-bisphosphate;    PLC;    phospholipase C;    PLD;    phospholipase D;   

DOI  :  10.1016/S0014-5793(98)01169-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

This work provides evidence that phosphatidic acid (PA) is metabolized to diacylglycerol pyrophosphate (DGPP) in Trypanosoma cruzi. Also the presence of the enzymatic activities involved in its regulation, phosphatidate kinase (PA-k) and phosphatidate phosphatase, is demonstrated. The increase of DGPP levels in T. cruzi epimastigotes or in its membrane fraction after exogenous PA addition or phospholipase (PLD) pre-treatment suggests that PA-k may be involved in the regulation of PA levels after its stimulation.

【 授权许可】

Unknown