Expression of type VI adenylyl cyclase in the central nervous system: implication for a potential regulator of multiple signals in different neurotransmitter systems

FEBS Letters

Chern, Yijuang³  Hsieh, Sung-Tsang¹  Lai, Hsing-Lin³  Liu, Fu-Chin²  Wu, Gour-Cheng³  Wang, Hsiao-Fang²  Wang, Tsu-Wei² 

[1] Department of Anatomy, College of Medicine, National Taiwan University, Taipei 100, Taiwan;Institute of Neuroscience, National Yang-Ming University, Taipei 112, Taiwan;Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan

关键词: Adenylyl cyclase;    Calcium;    Immunocytochemistry;    cAMP;    Brain;    Protein kinase C;   

DOI  :  10.1016/S0014-5793(98)01098-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The aim of this study was to investigate the distribution of a calcium-inhibitable adenylyl cyclase type VI (type VI AC) in the central nervous system using an antiserum directed against the N-terminus of type VI AC. Our results indicate that type VI AC immunoreactivity is generally expressed in many brain regions with different levels of intensity. Most interestingly, the majority of the detected type VI AC immunoreactivity is present in cells of neuronal phenotype. Double immunostaining of type VI AC and markers of various neurotransmitter systems suggest that type VI AC might participate in regulation of the classical neurotransmitter systems and therefore appeared to play a very important role in the central nervous system.

【 授权许可】

Unknown