期刊论文详细信息
FEBS Letters
Effects of a time‐varying strong magnetic field on transient increase in cytosolic free Ca2+ induced by bradykinin in cultured bovine adrenal chromaffin cells
Hosokawa, Keiko2  Yoshizaki, Kazuo2  Yamaguchi, Hisao2  Houchi, Hitoshi4  Tamaki, Toshiaki5  Miyamoto, Hiroshi1  Shono, Masayuki3  Park, Ki Ho6  Ikehara, Toshitaka2  Minakuchi, Kazuo4  Kinouchi, Yohsuke6 
[1] Department of Life, Environment and Information, Faculty of Domestic Science, Tokushima Bunri University, 180 Yamashiro-cho, Tokushima 770-8055, Japan;Department of Physiology, School of Medicine, The University of Tokushima, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan;General Laboratories for Medical Research, School of Medicine, The University of Tokushima, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan;Department of Pharmacy, School of Medicine, The University of Tokushima, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan;Department of Pharmacology, School of Medicine, The University of Tokushima, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan;Department of Electrical and Electronic Engineering, Faculty of Engineering, The University of Tokushima, 2-1 Minamijosanjima-cho, Tokushima 770-8506, Japan
关键词: Time-varying magnetic field;    Bovine adrenal chromaffin cell;    Ca2+ store;    Bradykinin;    Intracellular Ca2+;    Ca2+ influx;   
DOI  :  10.1016/S0014-5793(98)01078-3
学科分类:生物化学/生物物理
来源: John Wiley & Sons Ltd.
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【 摘 要 】

We tested the effects of exposure to a time-varying magnetic field changing between 0.07 and 1.7 T at an interval of 3 s on transient increase in intracellular Ca2+ stimulated by bradykinin in bovine adrenal chromaffin cells. Addition of bradykinin induced the increase in intracellular Ca2+ within a few minutes. The exposure to the magnetic field perfectly suppressed the increase in intracellular Ca2+ in Ca2+-free medium. The inhibition occurred for 15 min when the maximum magnetic flux density was more than 1.4 T. These results suggest that the exposure inhibits Ca2+ release from intracellular Ca2+ stores.

【 授权许可】

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