Effects of a time‐varying strong magnetic field on transient increase in cytosolic free Ca2+ induced by bradykinin in cultured bovine adrenal chromaffin cells

FEBS Letters

Hosokawa, Keiko²  Yoshizaki, Kazuo²  Yamaguchi, Hisao²  Houchi, Hitoshi⁴  Tamaki, Toshiaki⁵  Miyamoto, Hiroshi¹  Shono, Masayuki³  Park, Ki Ho⁶  Ikehara, Toshitaka²  Minakuchi, Kazuo⁴  Kinouchi, Yohsuke⁶ 

[1] Department of Life, Environment and Information, Faculty of Domestic Science, Tokushima Bunri University, 180 Yamashiro-cho, Tokushima 770-8055, Japan;Department of Physiology, School of Medicine, The University of Tokushima, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan;General Laboratories for Medical Research, School of Medicine, The University of Tokushima, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan;Department of Pharmacy, School of Medicine, The University of Tokushima, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan;Department of Pharmacology, School of Medicine, The University of Tokushima, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan;Department of Electrical and Electronic Engineering, Faculty of Engineering, The University of Tokushima, 2-1 Minamijosanjima-cho, Tokushima 770-8506, Japan

关键词: Time-varying magnetic field;    Bovine adrenal chromaffin cell;    Ca2+ store;    Bradykinin;    Intracellular Ca2+;    Ca2+ influx;   

DOI  :  10.1016/S0014-5793(98)01078-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We tested the effects of exposure to a time-varying magnetic field changing between 0.07 and 1.7 T at an interval of 3 s on transient increase in intracellular Ca²⁺ stimulated by bradykinin in bovine adrenal chromaffin cells. Addition of bradykinin induced the increase in intracellular Ca²⁺ within a few minutes. The exposure to the magnetic field perfectly suppressed the increase in intracellular Ca²⁺ in Ca²⁺-free medium. The inhibition occurred for 15 min when the maximum magnetic flux density was more than 1.4 T. These results suggest that the exposure inhibits Ca²⁺ release from intracellular Ca²⁺ stores.

【 授权许可】

Unknown