期刊论文详细信息
FEBS Letters
Glucocorticoids decrease cytochrome c oxidase activity of isolated rat kidney mitochondria
Jolliet, Pascale1  Tillement, Jean-Paul1  Morin, Christophe1  Simon, Nicolas1  Urien, Saı̈k1  Zini, Roland1 
[1] Départment de Pharmacologie, Faculté de Médecine de Paris XII, 8 rue du Général Sarrail, F-94010 Créteil, France
关键词: Mitochondria;    Glucocorticoid;    Oxidative phosphorylation;    Cytochrome c oxidase;   
DOI  :  10.1016/S0014-5793(98)01033-3
学科分类:生物化学/生物物理
来源: John Wiley & Sons Ltd.
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【 摘 要 】

The importance of mitochondria is rising as a target in pathologic processes such as ischemia. We have investigated the effects of hydrocortisone, prednisolone, dexamethasone and triamcinolone on oxidative phosphorylation, Ca2+ fluxes, swelling and membrane potentials in isolated kidney mitochondria. The measurement of respiration state 3 showed a significant decrease in presence of glucocorticoids whereas the other respiration states were not modified. When mitochondria were uncoupled and either the complexes III and IV or the complex IV were stimulated, the O2 consumption was decreased by glucocorticoids. These results suggest the cytochrome c oxidase is a target of the glucocorticoid effect on the respiratory chain. Indeed, the other mitochondrial functions investigated were unchanged, ruling out a direct effect on Ca2+ fluxes or swelling. A regulation of cytochrome c oxidase activity by glucocorticoids will be of particular interest in pathology involving metabolic insult.

【 授权许可】

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