FEBS Letters | |
Expression profile and structural divergence of novel human annexin 31 | |
Fernandez, Maria-Pilar1  Morgan, Reginald O.1  | |
[1] Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Oviedo, E-33006 Oviedo, Spain | |
关键词: Annexin multigene family; Calcium-binding site; Evolutionary divergence; Expressed sequence tag; Protein structure; Tissue distribution; aa; amino acid(s); ANX/ANXn-Gsp; human annexin gene/protein (suffixed by subfamily number and genus-species abbreviation); | |
DOI : 10.1016/S0014-5793(98)00997-1 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Systematic analysis of expressed sequence tags in dbEST yielded an expression profile of the ten known human annexins and led to the discovery of a novel subfamily expressed mainly in differentiating tissues. Full-length cDNAs encoded a 338-amino acid protein with less than 40% identity to other annexins, an atypical amino acid composition, and an insertion and deletion in internal repeat 3. The most striking feature was a complete ablation of all four type II calcium-binding sites in the conserved tetrad core. Annexin 31 thus constitutes a unique, natural probe for investigating the role of membrane binding in annexin function.
【 授权许可】
Unknown
【 预 览 】
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RO201912020306473ZK.pdf | 324KB | download |