Expression profile and structural divergence of novel human annexin 31

FEBS Letters

Fernandez, Maria-Pilar¹  Morgan, Reginald O.¹ 

[1] Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Oviedo, E-33006 Oviedo, Spain

关键词: Annexin multigene family;    Calcium-binding site;    Evolutionary divergence;    Expressed sequence tag;    Protein structure;    Tissue distribution;    aa;    amino acid(s);    ANX/ANXn-Gsp;    human annexin gene/protein (suffixed by subfamily number and genus-species abbreviation);   

DOI  :  10.1016/S0014-5793(98)00997-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Systematic analysis of expressed sequence tags in dbEST yielded an expression profile of the ten known human annexins and led to the discovery of a novel subfamily expressed mainly in differentiating tissues. Full-length cDNAs encoded a 338-amino acid protein with less than 40% identity to other annexins, an atypical amino acid composition, and an insertion and deletion in internal repeat 3. The most striking feature was a complete ablation of all four type II calcium-binding sites in the conserved tetrad core. Annexin 31 thus constitutes a unique, natural probe for investigating the role of membrane binding in annexin function.

【 授权许可】

Unknown