Association of extracellular‐superoxide dismutase phenotype with the endothelial constitutive nitric oxide synthase polymorphism

FEBS Letters

Li Wang, Xing²  Adachi, Tetsuo¹ 

[1] Laboratory of Clinical Pharmaceutics, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu, Japan;Department of Cardiovascular Medicine, University of New South Wales, Prince Henry/Prince of Wales Hospital, Sydney, Australia

关键词: Extracellular-superoxide dismutase;    Endothelial constitutive nitric oxide synthase;    Polymorphism;    Peroxynitrite;    Coronary artery disease;    EC-SOD;    extracellular-superoxide dismutase;    NO;    nitric oxide;    NOS;    nitric oxide synthase;    CAD;    coronary artery diseases;    NOx;    nitrite and nitrate;   

DOI  :  10.1016/S0014-5793(98)00903-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The distribution of extracellular-superoxide dismutase (EC-SOD) levels in healthy Australian subjects was consistent with two distinct phenotypes in which the smaller group of subjects (3.3%) had 15-fold higher levels. The EC-SOD levels in individuals homozygous for endothelial constitutive nitric oxide synthase 4a (ecNOS4a), a rare allele for ecNOS repeat polymorphism at intron 4, were significantly lower than those in ecNOS4A/a and ecNOS4A/A subjects. Furthermore, NO levels were negatively correlated with the EC-SOD levels in common EC-SOD phenotype subjects. Whilst the mechanism remains speculative, it is possible that there is a significant interaction between EC-SOD and ecNOS, or that common factor(s), either genetic or environmental, influence both of them.

【 授权许可】

Unknown