HIV: from molecular recognition to tissue pathogenesis

FEBS Letters

Margolis, Leonid¹ 

[1] Laboratory of Molecular and Cellular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Building 10, Room 10D14, Bethesda, MD 20892, USA

关键词: Human immunodeficiency virus type 1;    Molecular tropism;    Molecular recognition;   

DOI  :  10.1016/S0014-5793(98)00858-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Dramatic progress has been made recently in identifying both viral and cellular molecules responsible for binding and fusion of HIV-1 to target cells. In vivo, HIV-1 infection is transmitted by viruses that recognize chemokine receptor CCR5, while viruses isolated at later stages of HIV disease often recognize another chemokine receptor, CXCR4. It is still not understood how this molecular tropism of HIV-1 is translated into the virus' ability to compromise normal cell functions, which results in impairment of lymphoid tissue and causes AIDS. Here, we discuss how the new molecular findings might relate to HIV pathogenesis in cells and tissues.

【 授权许可】

Unknown