How do histone acetyltransferases select lysine residues in core histones?

FEBS Letters

Kimura, Akatsuki¹  Horikoshi, Masami¹ 

[1] Laboratory of Developmental Biology, Department of Cellular Biology, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan

关键词: Histone acetyltransferase;    Histone;    Site specificity;    Chromatin;   

DOI  :  10.1016/S0014-5793(98)00752-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Acetylation of specific lysines of core histone N-terminal tails correlates with chromatin assembly and specific regulation of gene expression. Core histones acetylated at particular lysines mediate effects on chromatin function; however, the manner in which different histone acetyltransferases (HATs) discriminate lysines is unknown. Here we propose a putative rule for lysine selection by HATs based on the primary sequence in the vicinity of lysines in the core histone N-terminal tails and in flanking sequence. This provides insight into the molecular basis of site selection of core histones by HATs.

【 授权许可】

Unknown