Differential effects of bacterial lipopolysaccharides upon neutrophil function

FEBS Letters

Riches, Philip L²  Ruivenkamp, Claudia A²  Poxton, Ian R¹  Ruchaud-Sparagano, Marie-Hélène²  Dransfield, Ian² 

[1] Medical Microbiology Department, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, UK;Rayne Laboratory, Respiratory Medicine Unit, University of Edinburgh Medical School, Teviot Place, Edinburgh EH8 9AG, UK

关键词: Inflammation;    Neutrophil;    Endotoxin;    LPS;    lipopolysaccharide;    LBP;    lipopolysaccharide binding protein;    TNF;    tumour necrosis factor;    fMLP;    formyl-Met-Leu-Phe;    PAF;    platelet activating factor;    ACLB;    albumin-coated latex beads;   

DOI  :  10.1016/S0014-5793(98)00686-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Lipopolysaccharide (LPS) is a potent inflammatory agent which augments neutrophil sensitivity to subsequent inflammatory stimuli. In this study, the effects of structurally different LPS types upon neutrophil effector functions were examined. Rough LPS types, which have lost the O-polysaccharide moiety, were found to act more rapidly than smooth LPS types in stimulating neutrophil β₂ integrin activity and fMLP-induced respiratory burst. These findings suggest an involvement of the O-polysaccharide region of LPS in regulating neutrophil responsiveness to different LPS chemotypes with important implications for the mechanisms underlying regulation of the inflammatory response in conditions associated with elevation of LPS in plasma, e.g. septic shock or acute respiratory distress syndrome.

【 授权许可】

Unknown