Measuring elasticity of biological materials by atomic force microscopy

FEBS Letters

Vinckier, Anja¹  Semenza, Giorgio¹ 

[1]Department of Biochemistry, Swiss Federal Institute of Technology, ETH Zentrum, Universitätstrasse 16, CH-8092 Zürich, Switzerland

关键词: Atomic force microscopy;    Elasticity;    Biomaterial;    Young's modulus;    Resolution;    AFM;    atomic force microscopy;    force curve;    force-versus-distance curve;    E;    Young's modulus or elastic modulus;    F;    force;    Δz;    indentation;    MTs;    microtubules;   

DOI  :  10.1016/S0014-5793(98)00592-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Atomic force microscopy (AFM) has proved its value not only for resolving the topographical structure of biological samples, but also for probing inherent properties of biological structures, like local interaction forces, mechanical properties or dynamics in a natural (physiological) environment. This minireview focuses on the acquisition of elasticity data of biomaterials by AFM. A possible theoretical model is presented, followed by a practical `how to do it with AFM', and, finally, a brief overview of publications in this field is given.

【 授权许可】

Unknown