Effects of IL‐1 receptor accessory protein on IL‐1 binding

FEBS Letters

Resch, K.¹  Wesche, H.¹  Martin, M.U.¹ 

[1] Institut für Molekularpharmakologie, Medizinische Hochschule Hannover, D-30625 Hannover, Germany

关键词: Interleukin-1 receptor;    IL-1 receptor accessory protein;    Interleukin-1 binding;   

DOI  :  10.1016/S0014-5793(98)00468-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Interleukin-1 (IL-1) is an important pro-inflammatory cytokine that exerts its diverse biological functions by binding to a receptor complex consisting of two transmembrane proteins, type I IL-1 receptor (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). Both receptor chains are indispensable for IL-1 signaling, but only IL-1RI is able to bind the cytokine. The effects of IL-1RAcP on IL-1 binding are unclear. This study shows that although expression of IL-1RAcP does not alter the equilibrium dissociation constant of IL-1, it has an effect on the non-equilibrium binding modus, most likely due to changes in on/off rates. This defines an additional function of IL-1RAcP: it stabilizes the active IL-1 receptor complex.

【 授权许可】

Unknown