FEBS Letters | |
Effects of IL‐1 receptor accessory protein on IL‐1 binding | |
Resch, K.1  Wesche, H.1  Martin, M.U.1  | |
[1] Institut für Molekularpharmakologie, Medizinische Hochschule Hannover, D-30625 Hannover, Germany | |
关键词: Interleukin-1 receptor; IL-1 receptor accessory protein; Interleukin-1 binding; | |
DOI : 10.1016/S0014-5793(98)00468-2 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Interleukin-1 (IL-1) is an important pro-inflammatory cytokine that exerts its diverse biological functions by binding to a receptor complex consisting of two transmembrane proteins, type I IL-1 receptor (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). Both receptor chains are indispensable for IL-1 signaling, but only IL-1RI is able to bind the cytokine. The effects of IL-1RAcP on IL-1 binding are unclear. This study shows that although expression of IL-1RAcP does not alter the equilibrium dissociation constant of IL-1, it has an effect on the non-equilibrium binding modus, most likely due to changes in on/off rates. This defines an additional function of IL-1RAcP: it stabilizes the active IL-1 receptor complex.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201912020306077ZK.pdf | 206KB | download |