Dipeptidyl peptidase IV (DP IV, CD26) is involved in regulation of DNA synthesis in human keratinocytes

FEBS Letters

Faust, Jürgen¹  Lendeckel, Uwe²  Vetter, Robert W³  Gollnick, Harald³  Neubert, Klaus¹  Bühling, Frank²  Mnich, Kati²  Ansorge, Siegfried²  Born, Ilona¹  Reinhold, Dirk² 

[1] Institute of Biochemistry, Martin-Luther-University Halle-Wittenberg, 06099 Halle, Germany;Institute of Experimental Internal Medicine, Department of Internal Medicine, Otto-von-Guericke-University Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany;Department of Dermatology and Venereology, Otto-von-Guericke-University Magdeburg, 39120 Magdeburg, Germany

关键词: Dipeptidyl peptidase IV;    Keratinocyte;    Synthetic inhibitor;    Proliferation;   

DOI  :  10.1016/S0014-5793(98)00502-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Various studies have shown that the membrane ectoenzyme dipeptidyl peptidase IV (DP IV, CD26), expressed on T, NK, and B cells in the human immune system, is involved in the regulation of DNA synthesis and cytokine production. Here, we clearly demonstrate that this enzyme is highly expressed also on human epidermal foreskin and split-skin keratinocytes and that the specific DP IV inhibitors Lys[Z(NO₂)]-thiazolidide, Lys[Z(NO₂)]-pyrrolidide inhibit the enzymatic activity as well as the DNA synthesis of these cells. These data demonstrate that CD26 plays a role also in regulation of DNA synthesis of epidermal keratinocytes and that the enzymatic activity is required for mediating these effects.

【 授权许可】

Unknown