Updated catalogue of homologues to human disease‐related proteins in the yeast genome

FEBS Letters

Sander, Chris²  Valencia, Alfonso¹  Andrade, Miguel A¹ 

[1] Protein Design Group, CNB-CSIC, Campus Universidad Autonoma, Cantoblanco, E-28049 Madrid, Spain;European Bioinformatics Institute, EMBL, Hinxton, Cambridge, UK

关键词: Human disease;    Yeast genome;    Sequence analysis;    Function prediction;    HDRP;    human disease-related protein;    WAS;    Wiskott-Aldrich syndrome;    WH;    WAS homology;    GBD;    GTPase binding domain;    snRNP;    small nuclear ribonucleoproteins;    aa;    amino acids;   

DOI  :  10.1016/S0014-5793(98)00277-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The recent availability of the full Saccharomyces cerevisiae genome offers a perfect opportunity for revising the number of homologues to human disease-related proteins. We carried out automatic analysis of the complete S. cerevisiae genome and of the set of human disease-related proteins as identified in the SwissProt sequence data base. We identified 285 yeast proteins similar to 155 human disease-related proteins, including 239 possible cases of human-yeast direct functional equivalence (orthology). Of these, 40 cases are suggested as new, previously undiscovered relationships. Four of them are particularly interesting, since the yeast sequence is the most phylogenetically distant member of the protein family, including proteins related to diseases such as phenylketonuria, lupus erythematosus, Norum and fish eye disease and Wiskott-Aldrich syndrome.

【 授权许可】

Unknown