Yeast putative transcription factors involved in salt tolerance

FEBS Letters

Serrano, Ramón²  Rios, Gabino²  Mendizabal, Iratxe¹  de Larrinoa, Iñigo F¹  Mulet, Jose M² 

[1] Departamento de Quı́mica Aplicada, Facultad de Ciencias Quı́micas, P° M. Lardizabal 3, 20009 San Sebastián, Spain;Instituto de Biologı́a Molecular y Celular de Plantas, Universidad Politécnica de Valencia-CSIC, Camino de Vera s/n, 46022 Valencia, Spain

关键词: Signal transduction;    Salt stress;    Leucine zipper;    Zinc finger;    Saccharomyces cerevisiae;    Calcineurin;   

DOI  :  10.1016/S0014-5793(98)00249-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Four putative yeast transcription factors (Hal6–9p) have been identified which upon overexpression in multicopy plasmids increase sodium and lithium tolerance. This effect is mediated, at least in part, by increased expression of the Ena1p Na⁺/Li⁺ extrusion pump. Hal6p and Hal7p are bZIP proteins and their gene disruptions affected neither salt tolerance nor ENA1 expression. Hal8p and Hal9p are putative zinc fingers and their gene disruptions decreased both salt tolerance and ENA1 expression. Therefore, Hal8p and Hal9p, but not Hal6p and Hal7p, qualify as transcriptional activators of ENA1 under physiological conditions. Hal8p seems to mediate the calcineurin-dependent part of ENA1 expression.

【 授权许可】

Unknown