Female sterility in mice lacking the basigin gene, which encodes a transmembrane glycoprotein belonging to the immunoglobulin superfamily

FEBS Letters

Kuno, Naohiko²  Muramatsu, Takashi²  Senda, Takao³  Fan, Qi-Wen²  Kadomatsu, Kenji²  Hagihara, Masako²  Mizutani, Shigehiko¹ 

[1]Department of Obstetrics and Gynecology, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan

[2]Department of Biochemistry, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan

[3]Department of Anatomy, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan

关键词: Azoospermia;    Fertilization;    Gene targeting;    Implantation;    Matrix metalloprotease;    Oocyte maturation;    Bsg;    basigin;    Ig;    immunoglobulin;    hCG;    human chorionic gonadotropin;    BSA;    bovine serum albumin;    PBS;    phosphate-buffered saline;   

DOI  :  10.1016/S0014-5793(98)00213-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Basigin (Bsg) is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. Bsg knock-out mice exhibit infertility of both sexes. Based on limited results, defective implantation has been considered to be the cause of the female infertility. We demonstrate here that disruption of the Bsg gene produces the failure of female reproductive processes including not only implantation but also fertilization. Bsg mRNA expression in cumulus cells and basolateral localization of the Bsg protein in the endometrial epithelium further support the importance of Bsg in these processes.

【 授权许可】

Unknown