Identification and characterization of a novel member of the dystrobrevin gene family

FEBS Letters

Ballabio, Andrea²  Quaderi, Nandita²  Rossi, Elena³  Nigro, Vincenzo⁴  Belsito, Angela⁴  Di Iorio, Giuseppe¹  Puca, Annibale Alessandro²  Sampaolo, Simone¹  Franco, Brunella²  Piluso, Giulio⁴ 

[1] Istituto di Scienze Neurologiche, Facoltà di Medicina, Seconda Università degli Studi di Napoli, Naples, Italy;Telethon Institute of Genetics and Medicine (TIGEM), San Raffaele Biomedical Science Park, Via Olgettina 58, 20132 Milan, Italy;Cattedra di Biologia Generale, Università degli Studi di Pavia and Servizio di Citogenetica, San Raffaele Biomedical Science Park, Milan, Italy;Istituto di Patologia Generale ed Oncologia, Seconda Università degli Studi di Napoli, Naples, Italy

关键词: Dystrobrevin B;    Dystrobrevin;    Dystrophin associated protein;    Monoclonal antibody A0;    DAP;    dystrophin associated protein;    DTN;    dystrobrevin;    DMD;    Duchenne muscular dystrophy;    RACE;    rapid amplification of cDNA ends;    VR;    variable region;    UTR;    untranslated region;   

DOI  :  10.1016/S0014-5793(98)00097-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A new member of the dystrobrevin gene family was identified using a bioinformatics approach. Sequence analysis indicates that this gene, named DTN-B, is highly homologous to the rabbit A0, the previously described dystrobrevin (DTN), Torpedo 87 kDa and to the C-terminus of dystrophin. The coiled-coil domain, shown to be the site of interaction between dystrobrevins and dystrophin, is highly conserved. Immunostaining studies indicate that DTN-B and DTN expression is absent in affected muscle fibers from DMD patients and carriers.

【 授权许可】

Unknown