In vitro interactions of Caenorhabditis elegans dystrophin with dystrobrevin and syntrophin

FEBS Letters

Ségalat, Laurent¹  Abdel-Dayem, Manal¹  Gieseler, Kathrin¹ 

[1] IMPC, CNRS-UPR411, 660 route des lucioles, 06560 Sophia Antipolis, France

关键词: Dystrophin;    Dystrobrevin;    Syntrophin;    Duchenne muscular dystrophy;    Nematode;   

DOI  :  10.1016/S0014-5793(99)01421-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Dystrophin, the product of the gene mutated in Duchenne muscular dystrophy (DMD) is bound by its C-terminus to a protein complex including the related protein dystrobrevin. Both proteins contain a putative coiled-coil domain consisting of two α-helices. It has been reported that the two proteins bind to each other by the first one of the two α-helices. We have revisited this question using the Caenorhabditis elegans homologs of dystrophin and dystrobrevin. In vitro interaction occurs through the more conserved second helix. We propose a new model of dystrophin interactions with associated proteins.

【 授权许可】

Unknown