Sulphite enhances peroxynitrite‐dependent α1‐antiproteinase inactivation. A mechanism of lung injury by sulphur dioxide?

FEBS Letters

Jenner, Peter¹  Halliwell, Barry¹  Reist, Marianne¹ 

[1] International Antioxidant Research Centre, Pharmacology Group, King's College, Manresa Road, London SW3 6LX, UK

关键词: Sulfite;    Sulfur dioxide;    Peroxynitrite;    α1-Antiproteinase;    Lung injury;    UV spectroscopy;   

DOI  :  10.1016/S0014-5793(98)00099-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Sulphite is toxic to the lung and can cause allergic reactions, the most common of which is bronchoconstriction in asthmatics. We show that sulphite can considerably potentiate the inactivation of α₁-antiproteinase caused by peroxynitrite. Addition of peroxynitrite to sulphite generated inactivating species that persisted at pH 7.4 and 37°C for at least 30 min. We propose that formation of protein-modifying sulphite radicals from SO²⁻ ₃ exposed to ONOO⁻ is a mechanism by which SO₂ could cause lung injury, both by enhancing proteolysis and by creating new antigens that could provoke an immune response.

【 授权许可】

Unknown