Crosstalk: phosphorylation of α1b‐adrenoceptors induced through activation of bradykinin B2 receptors

FEBS Letters

Mendoza-Mendoza, Artemio¹  Torres-Padilla, Marı́a Elena¹  Cruz-Muñoz, Mario Ernesto¹  Garcı́a-Sáinz, J.Adolfo¹  Medina, Luz del Carmen¹  Vázquez-Prado, José¹ 

[1] Department of Cell Biology, Instituto de Fisiologı́a Celular, UNAM, Apartado Postal 70-248, México D.F. 04510, Mexico

关键词: α1b-Adrenoceptor;    Receptor phosphorylation;    Bradykinin receptor;    Rat-1 fibroblast;    Desensitization;   

DOI  :  10.1016/S0014-5793(97)01615-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The possibility that bradykinin could modulate α_1b-adrenoceptors was studied. It was observed that bradykinin and kallidin increased α_1b-adrenoceptor phosphorylation and that such effect was also blocked by Hoe 140. Interestingly, the ability of norepinephrine to increase intracellular calcium concentration was not altered by pretreatment of the cells with bradykinin, i.e. bradykinin induced α_1b-adrenoceptor phosphorylation but this did not lead to receptor desensitization.

【 授权许可】

Unknown