期刊论文详细信息
FEBS Letters
Expression of the potassium channel KV3.4 in mouse skeletal muscle parallels fiber type maturation and depends on excitation pattern
Bartsch, Jörg W1  Vullhorst, Detlef1  Jockusch, Harald1  Klocke, Rainer1 
[1] Developmental Biology Unit, W7, University of Bielefeld, D-33501 Bielefeld, Germany
关键词: KV3.4;    Raw3;    Denervation;    Myotonia;    Reverse transcription polymerase chain reaction;   
DOI  :  10.1016/S0014-5793(97)01577-9
学科分类:生物化学/生物物理
来源: John Wiley & Sons Ltd.
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【 摘 要 】

We report the detailed expression pattern of the voltage-dependent potassium channel KV3.4 (rat homologue, Raw3) in mouse skeletal muscle. Using semi-quantitative RT-PCR, we show that its expression is detectable at embryonic day 17 and rises to adult levels within 2 weeks after birth. Expression is fiber type-dependent, with mRNA levels being 5–6-fold lower in the mixed slow/fast soleus muscle than in the fast tibialis anterior and extensor digitorum longus muscles. Fast muscles from myotonic mice exhibit low KV3.4 mRNA levels similar to those of wild-type soleus. In denervated extensor digitorum longus, KV3.4 expression declines to perinatal levels. We conclude that KV3.4 expression in mouse skeletal muscle is regulated by the pattern of excitation.

【 授权许可】

Unknown   

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