Periportal localization of glucagon receptor mRNA in rat liver and regulation of its expression by glucose and oxygen in hepatocyte cultures

FEBS Letters

Krones, Anja¹  Kietzmann, Thomas¹  Jungermann, Kurt¹ 

[1] Institut für Biochemie und Molekulare Zellbiologie, Georg-August-Universität, Humboldtallee 23, D-37073 Göttingen, Germany

关键词: Glucagon receptor;    Oxygen;    Glucose;    Metabolic zonation;    β-Act;    β-actin;    DIG;    digoxigenin;    Gcg;    glucagon;    GcgR;    glucagon receptor;    Glc;    glucose;    Ins;    insulin;    PCK1;    cytosolic phosphoenolpyruvate carboxykinase;   

DOI  :  10.1016/S0014-5793(97)01556-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Glucagon is the major hormone activating glycogenolysis and gluconeogenesis both localized in the periportal, more aerobic zone of the liver. Accordingly, the glucagon receptor (GcgR) mRNA was found to be predominantly expressed in this area. In hepatocyte cultures high glucose concentrations as reached after a meal induced GcgR mRNA under arterial but not venous pO₂. The induction by glucose was partially antagonized by insulin and unaffected by glucagon. The modulation by O₂ of the glucose-dependent induction would contribute to the zonated expression of GcgR mRNA.

【 授权许可】

Unknown