The aerobic/anaerobic transition of glucose metabolism in Trypanosoma brucei

FEBS Letters

Panes, Alison¹  Eisenthal, Robert¹ 

[1] Department of Biochemistry, University of Bath, Bath BA2 7AY, England

关键词: Trypanosoma brucei;    Glucose;    Glycolysis;    Oxygen;    Glycerol;    Pyruvate;    3GP;    L-glycerol-3-phosphate;    DHAP;    dihydroxyactone phosphate;    Po2;    partial pressure of oxygen;   

DOI  :  10.1016/0014-5793(85)81106-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The ratio of glycerol to pyruvate produced by T. brucei incubated with glucose at various oxygen tensions has been used as an index of the aerobic and anaerobic pathways of glucose metabolism. A minimal model is presented which fits the observed data. The value of the notional K of the aerobic/anaerobic transition from the model is close to that of the K _m of trypanosomal glycerophosphate oxidase. The anaerobic pathway appears to be almost completely inoperative at oxygen tensions in the range of those found in venous and arterial blood.

【 授权许可】

Unknown