Yeast gene YOR137c is involved in the activation of the yeast plasma membrane H+‐ATPase by glucose

FEBS Letters

de la Fuente, Natalia¹  Maldonado, Ana M¹  Portillo, Francisco¹ 

[1] Departamento de Bioquı́mica, Facultad de Medicina, Universidad Autónoma de Madrid and Instituto de Investigaciones Biomédicas del Consejo Superior de Investigaciones Cientı́ficas, Arturo Duperier 4, E-28029 Madrid, Spain

关键词: H+-ATPase;    Plasma membrane;    Glucose activation;    Saccharomyces cerevisiae;   

DOI  :  10.1016/S0014-5793(97)01478-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Glucose triggers transcriptional and post-transcriptional mechanisms that increase the level and activity of Saccharomyces cerevisiae plasma membrane H⁺-ATPase. We have studied the post-transcriptional activation of the enzyme by glucose and have found that the YOR137c gene product is implicated in this activation. Deletion of YOR137c does not affect the level of Pma1 at the plasma membrane, but disturbs the glucose-triggered V _max increase of the enzyme. We propose that at least two independent mechanisms are involved in glucose activation of the H⁺-ATPase.

【 授权许可】

Unknown