Enhanced expression of uncoupling protein 2 gene in rat white adipose tissue and skeletal muscle following chronic treatment with thyroid hormone

FEBS Letters

Kakuma, Tetsuya¹  Sakata, Toshiie¹  Yoshimatsu, Hironobu¹  Hidaka, Shuji¹  Masaki, Takayuki¹  Kurokawa, Mamoru¹ 

[1] Department of Internal Medicine 1, School of Medicine, Oita Medical University, Hasama, Oita 879-55, Japan

关键词: Uncoupling protein 2;    Hyperthyroidism;    Leptin;    Adipose tissue;    Skeletal muscle;    UCP;    uncoupling protein;    WAT;    white adipose tissue;    BAT;    brown adipose tissue;    β3-AR;    β3-adrenergic receptors;   

DOI  :  10.1016/S0014-5793(97)01404-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Evidence is rapidly emerging which suggests that uncoupling protein 2 (UCP2), by virtue of its ubiquitous expression, may be important for determining basal metabolic rate. To assess the functional modulation of UCP2 gene expression in relation to body weight control, we examined the effects of hyperthyroid state induced by chronic treatment with triiodothyronine (T₃) on UCP2 mRNA expression in male rats. Daily subcutaneous injection of T₃ (37 pmol/100 g body weight) for 7 days increased UCP2 mRNA expression in brown adipose tissue (BAT), white adipose tissue (WAT) and the soleus muscle 1.6-, 1.6- and 1.7-fold compared to the controls, respectively, and increased UCP1 mRNA expression in BAT 1.2-fold. In contrast, the same treatment with T₃ decreased both ob mRNA expression in WAT and plasma leptin level 0.5-fold for each. The present results suggest that T₃ may directly increase UCP2 expression independently of leptin action.

【 授权许可】

Unknown