Induction by peroxisome proliferators and triiodothyronine of serine:pyruvate/alanine:glyoxylate aminotransferase of rat liver

FEBS Letters

Oda, Toshiaki¹  Funai, Tsuneyoshi¹  Ichiyama, Arata¹ 

[1]Department of Biochemistry, Hamamatsu University School of Medicine, 3600 Handa-cho, Hamamatsu, Shizuoka 431-31, Japan

关键词: Peroxisome proliferator;    Triiodothyronine;    Enzyme induction;    Serine:pyruvate aminotransferase;    SPT;    serine:pyruvate aminotransferase;    AGT;    alanine:glyoxylate aminotransferase;    SPTm;    mitochondrial SPT;    SPTp;    peroxisomal SPT;    pSPTm;    precursor for SPTm;    T3;    triiodothyronine;    DEHP;    di-(2-ethylhexyl)phthalate;    SDS-PAGE;    sodium dodecyl sulfate-polyacrylamide gel electrophoresis;   

DOI  :  10.1016/S0014-5793(97)01396-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In rat liver, a single serine:pyruvate/alanine:glyoxylate aminotransferase (SPT or SPT/AGT) gene is transcribed from two transcription initiation sites. Transcription from the upstream site generates the mRNA encoding the precursor for mitochondrial SPT (pSPTm) and is markedly enhanced by the administration of glucagon or cAMP. In this report we show the increase in the downstream transcript, the peroxisomal SPT (SPTp) mRNA, caused by peroxisome proliferators and triiodothyronine (T₃). In the case of T₃, the pSPTm mRNA was also increased 72 h after a single administration of the hormone in addition to an earlier increase in SPTp mRNA.

【 授权许可】

Unknown