Characterisation of the rat and mouse homologues of gC1qBP, a 33 kDa glycoprotein that binds to the globular `heads' of C1q

FEBS Letters

Ghebrehiwet, Berhane³  Schwaeble, Wilhelm J²  Daha, Mohamed R⁵  Leigh, Leonora A.E¹  Reid, Kenneth B.M¹  van den Berg, Rocco H⁵  Lynch, Nicholas J²  Lim, Wallace B.L⁴ 

[1] M.R.C. Immunochemistry Unit, Department of Biochemistry, University of Oxford, Oxford, UK;Department of Microbiology and Immunology, University of Leicester, University Road, Leicester LE1 9HN, UK;Department of Medicine, State University of New York, New York, NY, USA;Department of Zoology, University of Hong Kong, Hong Kong, China;Department of Nephrology, University Hospital Leiden, Leiden, The Netherlands

关键词: gC1qBP;    C1q;    Complement;    Receptor;   

DOI  :  10.1016/S0014-5793(97)01348-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

gC1qBP is a 33 kDa glycoprotein that binds to the globular `heads' of C1q. We have cloned cDNAs encoding the rat and mouse homologues of gC1qBP. Comparison of the cDNA-derived amino acid sequences of gC1qBP reveals that either of the rodent sequences is 89.9% identical to the reported human sequence. Recombinant rat gC1qBP binds avidly to human C1q. gC1qBP mRNA is abundantly expressed in every rat and mouse tissue analysed. Rat mesangial cells synthesise gC1qBP, but do not express gC1qBP on the cell surface. In rat serum, gC1qBP is present at low levels.

【 授权许可】

Unknown