Activation of the binding of C1q to immune complexes by zinc

FEBS Letters

Easterbrook-Smith, S.B.¹ 

[1] Department of Biochemistry, University of Sydney, Sydney, NSW 2006, Australia

关键词: C1q;    Immune complex;    Complement;    Zinc;    Fluorescence;   

DOI  :  10.1016/0014-5793(83)81060-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

ZnSO₄ promotes the binding of C1q to immune complexes over the same concentration range (10⁻⁵−10⁻⁴ M) that it inhibits binding of C1 to cell-bound immunoglobulin [Biochem. Biophys. Res. Commun. (1981) 103, 856–862]. At higher concentrations (10⁻³−2 × 10⁻² M) ZnSO₄ inhibited the binding of C1q to immune complexes, [K _i = (6 ± 2) × 10⁻³ M]. This inhibition could be correlated with a ZnSO₄-induced change in the tryptophan fluorescence of C1q [ΔF 25%, K _d = (9.9 ± 1.0) × 10⁻³ M].

【 授权许可】

Unknown