期刊论文详细信息
FEBS Letters | |
The macrophage migration inhibitory factor MIF is a phenylpyruvate tautomerase | |
Björk, Peter3  Åman, Pierre1  Hansson, Christer4  Jacobsson, Lars2  Ahlfors, Stefan4  Thelin, Sofia1  Rorsman, Hans4  Rosengren, Evald2  | |
[1]Department of Clinical Genetics, University Hospital, S-221 85 Lund, Sweden | |
[2]Department of Pharmacology, University of Lund, S-223 62 Lund, Sweden | |
[3]Blood Center, University Hospital, S-221 85 Lund, Sweden | |
[4]Department of Dermatology, University Hospital, S-221 85 Lund, Sweden | |
关键词: Macrophage migration inhibitory factor; Phenylpyruvate tautomerase; d-Dopachrome tautomerase; Cytokine; | |
DOI : 10.1016/S0014-5793(97)01261-1 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
A macrophage migration inhibitory factor (MIF), originally described as a product of activated lymphocytes, has been defined as a 12 kDa protein, expressed in a wide variety of tissues. Here MIF is identified as a phenylpyruvate tautomerase (EC 5.3.2.1) having p-hydroxyphenylpyruvate and phenylpyruvate as its natural substrates. The definition of MIF as an enzyme may yield insight into the mechanism of action of this proinflammatory and immunomodulating cytokine.
【 授权许可】
Unknown
【 预 览 】
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