The macrophage migration inhibitory factor MIF is a phenylpyruvate tautomerase

FEBS Letters

Björk, Peter³  Åman, Pierre¹  Hansson, Christer⁴  Jacobsson, Lars²  Ahlfors, Stefan⁴  Thelin, Sofia¹  Rorsman, Hans⁴  Rosengren, Evald² 

[1] Department of Clinical Genetics, University Hospital, S-221 85 Lund, Sweden;Department of Pharmacology, University of Lund, S-223 62 Lund, Sweden;Blood Center, University Hospital, S-221 85 Lund, Sweden;Department of Dermatology, University Hospital, S-221 85 Lund, Sweden

关键词: Macrophage migration inhibitory factor;    Phenylpyruvate tautomerase;    d-Dopachrome tautomerase;    Cytokine;   

DOI  :  10.1016/S0014-5793(97)01261-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A macrophage migration inhibitory factor (MIF), originally described as a product of activated lymphocytes, has been defined as a 12 kDa protein, expressed in a wide variety of tissues. Here MIF is identified as a phenylpyruvate tautomerase (EC 5.3.2.1) having p-hydroxyphenylpyruvate and phenylpyruvate as its natural substrates. The definition of MIF as an enzyme may yield insight into the mechanism of action of this proinflammatory and immunomodulating cytokine.

【 授权许可】

Unknown