Characterization of two receptors for TRAIL

FEBS Letters

Bodmer, Jean-Luc²  Thome, Margot²  Tschopp, Jürg²  Schneider, Pascal²  Hofmann, Kay¹  Holler, Nils² 

[1] Swiss Institute for Experimental Cancer Research, BIL Research Center, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland;Institute of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland

关键词: Apoptosis;    Death receptor;    TRAIL;    Tumor necrosis factor;   

DOI  :  10.1016/S0014-5793(97)01231-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Two receptors for TRAIL, designated TRAIL-R2 and TRAIL-R3, have been identified. Both are members of the tumor necrosis factor receptor family. TRAIL-R2 is structurally similar to the death-domain-containing receptor TRAIL-R1 (DR-4), and is capable of inducing apoptosis. In contrast, TRAIL-R3 does not promote cell death. TRAIL-R3 is highly glycosylated and is membrane bound via a putative phosphatidylinositol anchor. The extended structure of TRAIL-R3 is due to the presence of multiple threonine-, alanine-, proline- and glutamine-rich repeats (TAPE repeats). TRAIL-R2 shows a broad tissue distribution, whereas the expression of TRAIL-R3 is restricted to peripheral blood lymphocytes (PBLs) and skeletal muscle. All three TRAIL receptors bind TRAIL with similar affinity, suggesting a complex regulation of TRAIL-mediated signals.

【 授权许可】

Unknown