FEBS Letters | |
Characterization of two receptors for TRAIL | |
Bodmer, Jean-Luc2  Thome, Margot2  Tschopp, Jürg2  Schneider, Pascal2  Hofmann, Kay1  Holler, Nils2  | |
[1] Swiss Institute for Experimental Cancer Research, BIL Research Center, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland;Institute of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland | |
关键词: Apoptosis; Death receptor; TRAIL; Tumor necrosis factor; | |
DOI : 10.1016/S0014-5793(97)01231-3 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Two receptors for TRAIL, designated TRAIL-R2 and TRAIL-R3, have been identified. Both are members of the tumor necrosis factor receptor family. TRAIL-R2 is structurally similar to the death-domain-containing receptor TRAIL-R1 (DR-4), and is capable of inducing apoptosis. In contrast, TRAIL-R3 does not promote cell death. TRAIL-R3 is highly glycosylated and is membrane bound via a putative phosphatidylinositol anchor. The extended structure of TRAIL-R3 is due to the presence of multiple threonine-, alanine-, proline- and glutamine-rich repeats (TAPE repeats). TRAIL-R2 shows a broad tissue distribution, whereas the expression of TRAIL-R3 is restricted to peripheral blood lymphocytes (PBLs) and skeletal muscle. All three TRAIL receptors bind TRAIL with similar affinity, suggesting a complex regulation of TRAIL-mediated signals.
【 授权许可】
Unknown
【 预 览 】
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