An estrogen inducible 104 kDa chaperone glycoprotein binds ferric iron containing proteins: a possible role in intracellular iron trafficking

FEBS Letters

Poola, Indra¹ 

[1]Departments of Pharmacology and Biochemistry and Molecular Biology, Howard University School of Medicine, 520 W. Street, NW, Washington D.C. 20059, USA

关键词: Estrogen-inducible membrane glycoprotein;    Intracellular iron trafficking;    Transferrin;    Lactoferrin;    Microbial ferric binding protein;    Chaperone protein;    EIMG;    estrogen inducible membrane glycoprotein;    FBP;    ferric binding protein;   

DOI  :  10.1016/S0014-5793(97)01183-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have previously described an estrogen inducible, intracellular, homodimeric membrane glycoprotein (subunit M _r 104 kDa) which is structurally related to ‘chaperone’ proteins (Poola, I. and Kiang J.G., J. Biol. Chem. 269 (1994) 21762–21769). In this report we describe a novel finding that the 104 kDa chaperone protein exhibits affinity for iron containing proteins such as transferrins from several species, human lactoferrin and microbial ferric binding protein (FBP). A single ferric ion in the above proteins appears to be sufficient for binding. It also binds to immobilized ferritin. However, it does not exhibit any affinity for apotransferrins, apolactoferrin, apoferritin and apoFBP. This is the first report of a chaperone protein that exhibits affinity for iron containing proteins.

【 授权许可】

Unknown