期刊论文详细信息
FEBS Letters | |
Mechanisms of cycloheximide‐induced apoptosis in liver cells | |
Makarieva, Elena D1  Loginov, Anatoliy S1  Boikov, Peter Ya1  Filippova, Galina N1  Khrenov, Alexey V1  Alessenko, Alice V1  | |
[1] Institute of Biochemical Physics RAS, 4 Kosygin str., Moscow 117977, Russia | |
关键词: Apoptosis; Cycloheximide; Sphingosine; c-myc gene expression; c-fos gene expression; c-jun gene expression; p53 gene expression; | |
DOI : 10.1016/S0014-5793(97)01161-7 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Cycloheximide in sublethal doses caused apoptosis in liver cells in vivo, inducing c-myc, c-fos, c-jun and p53 genes and accumulation of sphingosine, a toxic product of the sphingomyelin cycle. These data support the hypothesis that continuous synthesis of labile protective proteins is required to restrain apoptosis in liver; sphingosine might be important in mediating cycloheximide-induced apoptosis as an endogenous modulator of protein kinase C activity.
【 授权许可】
Unknown
【 预 览 】
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