期刊论文详细信息
FEBS Letters
Mechanisms of cycloheximide‐induced apoptosis in liver cells
Makarieva, Elena D1  Loginov, Anatoliy S1  Boikov, Peter Ya1  Filippova, Galina N1  Khrenov, Alexey V1  Alessenko, Alice V1 
[1] Institute of Biochemical Physics RAS, 4 Kosygin str., Moscow 117977, Russia
关键词: Apoptosis;    Cycloheximide;    Sphingosine;    c-myc gene expression;    c-fos gene expression;    c-jun gene expression;    p53 gene expression;   
DOI  :  10.1016/S0014-5793(97)01161-7
学科分类:生物化学/生物物理
来源: John Wiley & Sons Ltd.
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【 摘 要 】

Cycloheximide in sublethal doses caused apoptosis in liver cells in vivo, inducing c-myc, c-fos, c-jun and p53 genes and accumulation of sphingosine, a toxic product of the sphingomyelin cycle. These data support the hypothesis that continuous synthesis of labile protective proteins is required to restrain apoptosis in liver; sphingosine might be important in mediating cycloheximide-induced apoptosis as an endogenous modulator of protein kinase C activity.

【 授权许可】

Unknown   

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