Molecular characterization of a novel human PDZ domain protein with homology to INAD from Drosophila melanogaster

FEBS Letters

Flockerzi, Veit¹  Philipp, Stephan¹ 

[1] Pharmakologisches Institut der Universität Heidelberg, Im Neuenheimer Feld 366, D-69120 Heidelberg, Germany

关键词: PDZ domain;    INAD;    GLGF repeat;    Capacitative calcium entry;    Membrane protein cluster;    DHR domain;   

DOI  :  10.1016/S0014-5793(97)00877-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

PDZ domains are thought to act as protein-binding modules mediating the clustering of membrane and membrane-associated proteins. The INAD protein has been shown to interact via a PDZ domain with the calcium channel TRP which contributes to capacitative calcium entry into Drosophila photoreceptor cells. We have cloned the cDNA of a human INAD-Like protein (hINADL) of 1524 amino acids in length containing at least five PDZ domains. Additionally, two truncated versions hINADL _Δ304 and hINADL _Δ853 were identified. hInadl transcripts of differing size are expressed in various tissues including brain, where transcripts are abundant in the cerebellum.

【 授权许可】

Unknown