期刊论文详细信息
FEBS Letters | |
Distinct type‐2A protein phosphatases activate HMGCoA reductase and acetyl‐CoA carboxylase in liver | |
Hardie, D.Grahame1  Hue, Louis2  Skarlas, Polymnia2  Ching, Yick Pang1  Gaussin, Vinciane2  | |
[1] Biochemistry Department, Dundee University, Dundee, DD1 4HN Scotland, UK;Hormone and Metabolic Research Unit, International Institute of Cellular and Molecular Pathology, Louvain University Medical School, Avenue Hippocrate 75, Brussels B-1200, Belgium | |
关键词: Acetyl-CoA carboxylase; AMP-activated protein kinase; Glutamine; HMGCoA reductase; Protein phosphatase-2A; ACC; acetyl-CoA carboxylase; AICAriboside; 5-amino 4-imidazolecarboxamide riboside; AMPK; AMP-activated protein kinase; GAPP; hepatic glutamate-activated protein phosphatase; HMGCoA; hydroxymethylglutaryl coenzyme A; PP; protein phosphatase; | |
DOI : 10.1016/S0014-5793(97)00890-9 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Acetyl-CoA carboxylase and HMGCoA reductase are inactivated by the same AMP-activated protein kinase and are activated by type-2A protein phosphatase. To determine whether the same species of protein phosphatase-2A were involved, we studied the interconversion of acetyl-CoA carboxylase and HMGCoA reductase in isolated rat hepatocytes. We show that (i) these enzymes are differently regulated in hepatocytes and (ii) the species of type-2A protein phosphatase involved in their activation are different and can be separated by anion-exchange chromatography.
【 授权许可】
Unknown
【 预 览 】
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