Aging decreases the abundance of retinoic acid (RAR) and triiodothyronine (TR) nuclear receptor mRNA in rat brain: effect of the administration of retinoids

FEBS Letters

Jaffard, R³  Higueret, P¹  Pallet, V¹  Enderlin, V¹  Garcin, H¹  Azaı̈s-Braesco, V²  Alfos, S¹ 

[1] Laboratoire de Nutrition, ISTAB, Av. des Facultés, Université Bordeaux I, 33405 Talence, France;Centre de Recherche en Nutrition Humaine, INRA, B.P. 321, 63009 Clermont-Ferrand, France;Laboratoire des Neurosciences Comportementales et Cognitives, Av. des Facultés, Université Bordeaux I, 33405 Talence, France

关键词: Aging;    Nuclear receptor;    RAR;    TR;    mRNA;    Retinoid;   

DOI  :  10.1016/S0014-5793(97)00845-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Aging is accompanied by troubles resulting from changes in hormonal and nutritional status. Therefore, the abundance of mRNA coding for triiodothyronine (TR) and retinoic acid (RA) nuclear receptors was studied in the brain of young, adult and aged (2.5, 6 and 24 months, respectively) rats. In the brain of aged rats, there was a lower abundance of TR and RAR mRNA and a lower activity of tissue transglutaminase (tTG), an enzyme the gene of which is a target for retinoids. Administration of RA in these rats restored TR and RAR mRNA and the activity of tTG in the brain. The importance of these observations to the function of the aged brain is discussed.

【 授权许可】

Unknown