Cloning and expression of an alternatively spliced mRNA encoding a soluble form of the human interleukin‐6 signal transducer gp130

FEBS Letters

Diamant, Marcus¹  Zhang, Xue-Guang²  Bendtzen, Klaus¹  Svenson, Morten¹  Klein, Bernard²  Mechti, Nadir²  Rieneck, Klaus¹ 

[1] Institute for Inflammation Research, Rigshospitalet, 7544, Tagensvej 20, DK-2200 Copenhagen N, Denmark;Institute of Molecular Genetics, CNRS, BP 5051, 1919 Route de Mende, 34033 Montpellier, France

关键词: gp130;    Soluble receptor;    Alternative splicing;   

DOI  :  10.1016/S0014-5793(97)00750-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Both gp130 and alternatively spliced sgp130 were also transcribed by the myeloma cell lines XG-1, XG-2, XG-4, XG-4CNTF XG-6, XG-7, XG-9, XG-10, U266 and RPMI 8226. However, XG-4A cells derived from XG-4 cells, but growing independently of exogenous IL-6, did not transcribe sgp130 mRNA. A possible interference with intracrine stimulatory factors by alternatively spliced sgp130 needs to be further investigated.

【 授权许可】

Unknown