Fungal cleavage of thioether bond found in Yperite

FEBS Letters

Wariishi, Hiroyuki¹  Itoh, Noriyuki¹  Miyamoto, Tadashi¹  Yoshida, Michiko¹  Ichinose, Hirofumi¹  Tanaka, Hiroo¹ 

[1] Department of Forest Products, Kyushu University, 6-10-1, Hakozaki, Higashi-ku, Fukuoka 812-81, Japan

关键词: Basidiomycete;    Benzyl sulfide;    Bioremediation;    Chemical warfare agent;    Thiodiglycol;    Yperite;   

DOI  :  10.1016/S0014-5793(97)00812-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The degradation of thiodiglycol (I) and benzyl sulfide (II) was attempted using Coriolus versicolor and Tyromyces palustris to investigate the potential ability of basidiomycetes to degrade Yperite (bis(2-chloroethyl) sulfide), a mass-produced and stored chemical warfare agent. I was very rapidly degraded by both fungi. The metabolic pathway of II was elucidated, showing that the initial step was the hydrolytic cleavage of the thioether bond to yield benzyl alcohol and benzyl mercaptan. Benzyl alcohol was further oxidized and finally mineralized. Benzyl mercaptan is reversibly converted to benzyl disulfide and also converted to benzyl alcohol. Finally, the effective degradation of bis(2-bromoethyl) sulfide strongly suggests that basidiomycete would be a potential tool for Yperite degradation.

【 授权许可】

Unknown