FEBS Letters | |
Tyrosine: an inhibitor of LDL oxidation and endothelial cell cytotoxicity initiated by superoxide/nitric oxide radicals | |
Hermann, Marcela3  Mühl, Adolf1  Held, Irmtraud4  Gmeiner, Bernhard4  Kapiotis, Stylianos2  | |
[1] Department of Pediatrics, University of Vienna, Vienna, Austria;Clinical Institute of Medical and Chemical Laboratory Diagnostics, University of Vienna, Vienna, Austria;Institute of Molecular Genetics, University of Vienna, Vienna, Austria;Institute of Medical Chemistry, University of Vienna, Währingerstr. 10, Vienna A-1090, Austria | |
关键词: LDL oxidation; Superoxide; Nitric oxide; Antioxidant; Tyrosine; SIN-1; | |
DOI : 10.1016/S0014-5793(97)00513-9 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Tyrosyl radicals can catalyze LDL oxidation. In addition to their LDL oxidizing ability, superoxide (O2 ·−)/nitric oxide (NO·) generate phenoxyl radicals when reacting with tyrosine. Therefore we tested if tyrosine can act as a pro-oxidant in O2 ·−/NO·-initiated LDL oxidation. When LDL was exposed to O2 ·−/NO·, tyrosine exerted a strong inhibitory effect on O2 ·−/NO·-initiated LDL oxidation as measured by TBARS formation and alteration in electrophoretic mobility of LDL. Tyrosine was also able to protect human endothelial cells from the cytotoxic effect of O2 ·−/NO·. Because O2 ·−/NO· can occur in vivo, the results may indicate that serum-free tyrosine could act as an efficacious physiological antioxidant in case of O2 ·−/NO·-initiated LDL oxidation and endothelial cell cytotoxicity.
【 授权许可】
Unknown
【 预 览 】
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