FEBS Letters | |
Lipoxygenase inhibitors block CD95 ligand‐mediated apoptosis of human malignant glioma cells | |
Gulbins, Erich2  Weller, Michael1  Lang, Florian2  Dichgans, Johannes1  Wagenknecht, Bettina1  | |
[1] Department of Neurology, University of Tübingen, School of Medicine, Hoppe-Seyler-Strasse 3, 72076 Tübingen, Germany;Institute of Physiology, University of Tübingen, School of Medicine, 72076 Tübingen, Germany | |
关键词: Glioma; CD95; Nordihydroguaretic acid; Lipoxygenase; Apoptosis; Arachidonic acid; | |
DOI : 10.1016/S0014-5793(97)00468-7 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
CD95 ligand is a cytotoxic cytokine that induces apoptosis. Here we report that CD95-mediated apoptosis of human malignant glioma cells is associated with arachidonic acid (AA) release. Inhibitors of phospholipase A2, phospholipase C or diacylglycerol lipase have minor effects on AA release and fail to modulate apoptosis. Formation of two AA metabolites generated during CD95-dependent apoptosis is attenuated by the lipoxygenase inhibitor, nordihydroguaretic acid (NDGA). NDGA also blocks CD95 ligand-induced apoptosis. This effect is independent of antioxidant properties of NDGA. Lipoxygenase may thus play a critical role in CD95 ligand-induced apoptosis of human malignant glioma cells.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201912020304351ZK.pdf | 708KB | download |