期刊论文详细信息
FEBS Letters | |
Production of formyl‐CoA during peroxisomal α‐oxidation of 3‐methyl‐branched fatty acids | |
Van Veldhoven, Paul P1  Casteels, Minne1  Croes, Kathleen1  Mannaerts, Guy P1  | |
[1] Katholieke Universiteit Leuven, Afdeling Farmacologie, Campus Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium | |
关键词: Hydrolase; Phytanic acid; Refsum's disease; | |
DOI : 10.1016/S0014-5793(97)00343-8 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
α-Oxidation of 3-methyl-substituted fatty acids was studied in purified rat liver peroxisomes. The experiments revealed that formyl-CoA is formed during the α-oxidation process. The amount of formyl-CoA found constituted 2–5% of the amount of formate formed. Under the conditions used, no activation of exogenously added formate occurred in purified peroxisomes, whereas 95.5% of added synthetic formyl-CoA was converted to formate. These data indicate that during α-oxidation first formyl-CoA is formed, which is then hydrolysed to formate.
【 授权许可】
Unknown
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