Effect of repeated experience of victory and defeat in daily agonistic confrontations on brain tryptophan hydroxylase activity

FEBS Letters

Amstislavskaya, Tamara G¹  Kudryavtseva, Natalia N¹ 

[1] Institute of Cytology and Genetics, Siberian Department of Russian Academy of Sciences, Novosibirsk State University, Pr.ak.Lavrentjeva, 10, 630090 Novosibirsk, Russia

关键词: Tryptophan hydroxylase;    Aggression;    Submission;    Serotonin;    Mouse;    Agonistic behavior;    Sensory contact technique;   

DOI  :  10.1016/S0014-5793(97)00252-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The rate-limiting enzyme of serotonin biosynthesis, tryptophan hydroxylase (TPH), was studied in brain areas of male mice with repeated experience of victory (winners) or defeat (losers) gained in 10 daily agonistic confrontations. A reduction of TPH activity in the midbrain and an increase in the hypothalamus was demonstrated for winners compared with controls. In contrast, repeated defeat in social confrontations was associated with higher TPH activity in the striatum and hypothalamus in losers compared with controls. Agonistic interactions did not affect TPH activity in the amygdala, nucleus accumbens or hippocampus in either winners or losers. The sensory contact technique used in this work for generating winners and losers may be productive in the analysis of TPH gene regulation.

【 授权许可】

Unknown